Key result
Genetic DIVA testing successfully distinguished C-strain vaccine from challenge viruses in tonsil homogenates, revealing that non-viraemic, incompletely protected pigs can harbor challenge virus.
Population
Pigs vaccinated with C-strain and challenged with classical swine fever virus
Design
Preclinical
Authors
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Highlights undetected challenge virus reservoirs in vaccinated pigs; leaves open DIVA integration into field control programs pending validation.
Genetic DIVA testing can detect field virus infection in vaccinated pigs without clinical signs, aiding in disease control strategies.
Everett et al. (2014) studied Classical swine fever (n=44). C-strain vaccine vs. Mock vaccination was evaluated on Detection of CSFV RNA (vaccine vs challenge strain) in tonsil extracts. Genetic DIVA testing successfully distinguished C-strain vaccine from challenge viruses in tonsil homogenates, revealing that non-viraemic, incompletely protected pigs can harbor challenge virus.
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