Key result
Locking hemodialysis tunneled catheters with TauroLock™ resulted in similar complication rates (6.7%) compared to a combination of gentamicin and heparin (6.7%) over 6 months.
Why the study?
Catheter-associated infections and thrombosis are major complications of tunneled hemodialysis catheters, prompting an evaluation of their incidence under prophylactic locking strategies.
Does locking hemodialysis tunneled catheters with TauroLock™ prevent catheter-related infections and thrombosis compared to a combination of gentamicin and heparin?
Population
45 hemodialysis patients with tunneled catheters placed >3 months ago as sole vascular access
Comparison
TauroLock vs gentamicin plus heparin vs 3 months TauroLock then 3 months gentamicin plus heparin
Design
Randomized study
Follow-up
6 months
Authors
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TauroLock™ offers a comparable locking option to gentamicin-heparin; RCT confirms similar efficacy for preventing tunneled hemodialysis catheter complications.
RCT (n=45)
Randomly divided
Does locking hemodialysis tunneled catheters with TauroLock™ prevent catheter-related infections and thrombosis compared to a combination of gentamicin and heparin?
Absolute Event Rate: 6.67% vs 6.67%
Locking hemodialysis catheters with TauroLock™ is comparable in efficacy to a gentamicin and heparin combination for preventing catheter-related complications, despite higher short-term costs.
Borisov et al. (2023) conducted an RCT in Hemodialysis with tunneled catheters (n=45). TauroLock™ vs. Gentamicin (10 mg/ml) and heparin (1250 IU/ml) was evaluated on Catheter-related infection (CRI) and catheter-related thrombosis (CRT). Locking hemodialysis tunneled catheters with TauroLock™ resulted in similar complication rates (6.7%) compared to a combination of gentamicin and heparin (6.7%) over 6 months.
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