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September 5, 2025Journal of NephropathologyOpen Access

Citrate versus heparin lock in hemodialysis catheter’s complications; a randomized clinical trial

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Randomized clinical trial shows no increased infection risk in hemodialysis patients using sodium citrate, suggesting effective catheter maintenance.

The administration of a 4% sodium citrate lock solution was linked to fewer changes in PTT compared to heparin locks, demonstrating its potential safety.
A significant difference in PTT changes was noted between the Citra-Lock and heparin-lock groups (P<0.001), showing citrate's effectiveness in coagulation.
58 patients undergoing chronic hemodialysis participated in this randomized clinical trial, comparing the two lock solutions directly.
The findings indicate that sodium citrate does not increase the risk of catheter-related complications, highlighting its viability as a lock solution.

Vajargah et al. (2025) studied this question.

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Randomized clinical trial shows no increased infection risk in hemodialysis patients using sodium citrate, suggesting effective catheter maintenance.