What question did this study set out to answer?

This research aims to compare the efficacy and safety of low-concentration trisodium citrate and unfractionated heparin in preventing catheter dysfunction for hemodialysis patients.

March 15, 2026Renal FailureOpen Access

Comparative efficacy of low-concentration trisodium citrate and low-concentration heparin for locking central venous hemodialysis catheters: a randomized controlled study

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PPPattharawin PattharanitimaThammasat University KWKwansuphang Wongwatanasanti PTPichaya TantiyavarongThammasat University

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Implication

Randomized controlled study compares outcomes of TSC and UFH in hemodialysis patients, suggesting similar efficacy and safety profiles.

Key Points

This research aims to compare the efficacy and safety of low-concentration trisodium citrate and unfractionated heparin in preventing catheter dysfunction for hemodialysis patients.
Randomized allocation of 204 hemodialysis patients to receive low-concentration TSC or UFH as catheter-locking anticoagulants.
Primary outcome measured was catheter dysfunction rate, with secondary outcomes including infections and bleeding events.
Follow-up for outcomes was conducted over 180 days post-intervention.
Catheter dysfunction rates were 1.11 for TSC and 1.73 for UFH per 1,000 catheter-days, with no significant difference (p = 0.23).
Rates of catheter-related bloodstream infections and exit site infections were similar between the two groups.
No significant differences were found in bleeding events or mortality rates between TSC and UFH.

Cite This Study

Pattharanitima et al. (2026) studied this question.

synapsesocial.com/papers/69b64d48b42794e3e660e165 https://doi.org/10.1080/0886022x.2026.2641842

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Comparative efficacy of low-concentration trisodium citrate and low-concentration heparin for locking central venous hemodialysis catheters: a randomized controlled study

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Cite This Study

Comparative efficacy of low-concentration trisodium citrate and low-concentration heparin for locking central venous hemodialysis catheters: a randomized controlled study

Discussion

Member takes

Implication

Key Points

Cite This Study

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