Why the study?
Does heparin 1000 U/mL compared to 10,000 U/mL for catheter locks increase tissue plasminogen activator use in patients with tunneled cuffed hemodialysis catheters?
Population
64 patients using tunneled cuffed hemodialysis catheters for at least 3 months in 2 in-center hemodialysis…
Comparison
Heparin 1000 U/mL for catheter locks vs Heparin 10,000 U/mL for catheter locks
Design
Cohort
Follow-up
6 months (between 11/04 and 5/05)
Authors
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Should not yet change catheter lock practices; leaves open comparative effectiveness and cost trade-offs pending randomized trials.
Does heparin 1000 U/mL compared to 10,000 U/mL for catheter locks increase tissue plasminogen activator use in patients with tunneled cuffed hemodialysis catheters?
Using 10,000 U/mL heparin as a catheter lock is associated with less frequent use of tpa compared to 1000 U/mL, though the lower concentration may offer overall cost savings.
Holley et al. (2007) studied this question.
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