Key result
Trisodium citrate 4% appears to provide a safe and at least equivalent alternative to unfractionated heparin as a hemodialysis catheter locking agent.
Why the study?
Does trisodium citrate 4% provide a safe and effective alternative to unfractionated heparin for hemodialysis catheter dwells?
Population
Patients requiring tunneled hemodialysis catheters (permcaths) for temporary or long-term dialysis access
Comparison
Trisodium citrate as a catheter locking solution vs Unfractionated heparin
Design
Review
Authors
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May support citrate locks in select hemodialysis patients; leaves open confirmation via randomized trials before practice change.
Does trisodium citrate 4% provide a safe and effective alternative to unfractionated heparin for hemodialysis catheter dwells?
Trisodium citrate 4% is a safe, cost-effective, and efficacious alternative to unfractionated heparin for maintaining hemodialysis catheter patency.
Pierce et al. (2010) conducted a review in Hemodialysis. Trisodium citrate vs. Unfractionated heparin was evaluated. Trisodium citrate 4% appears to provide a safe and at least equivalent alternative to unfractionated heparin as a hemodialysis catheter locking agent.
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