Key result
In patients with myocardial infarction, a 1 mmol/L increase in free fatty acid levels at day 1 was associated with a 2.9-fold increased risk of insulin resistance (OR 2.90).
Population
200 patients (130 males and 70 females aged 61.4 ± 1.12 years) diagnosed with ST elevation MI.
Design
Cohort
Follow-up
12 days
Authors
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IR dynamics post-STEMI may aid early risk stratification; Level 5 data leave open whether targeting IR improves outcomes.
Observational (n=200)
No
Odds Ratio: 2.9 (95% CI 1.38–6.11)
p-value: p=0.005
Dyslipidaemia, characterized by high free fatty acids, adipokine imbalance, and ghrelin deficiency, is a significant feature of insulin resistance in the acute and early recovery phases of STEMI.
Груздева et al. (2014) conducted an observational in ST elevation myocardial infarction (STEMI) (n=200). Elevated free fatty acid (FFA) levels vs. Lower free fatty acid levels was evaluated on Risk of insulin resistance per 1 mmol/L increase in FFA at day 1 (OR 2.90, 95% CI 1.38-6.11, p=0.005). In patients with myocardial infarction, a 1 mmol/L increase in free fatty acid levels at day 1 was associated with a 2.9-fold increased risk of insulin resistance (OR 2.90).
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