Key result
Continuing antithrombotics after ulcer bleeding is linked to more rebleeding but lower mortality and CVD.
Why the study?
Does continuing antithrombotics affect the risk of recurrent bleeding, death, and cardiovascular disease in peptic ulcer patients after ulcer bleeding?
Cohort
Does continuing antithrombotics affect the risk of recurrent bleeding, death, and cardiovascular disease in peptic ulcer patients after ulcer bleeding?
In patients with peptic ulcer bleeding, continuing antithrombotics presents a clinical trade-off, increasing recurrent bleeding risk but preventing death and cardiovascular disease compared to discontinuation.
May warrant individualized antithrombotic decisions after peptic ulcer bleed; leaves open optimal strategy pending randomized trials.
AIM: To investigate the long-term prognosis in peptic ulcer patients continuing taking antithrombotics after ulcer bleeding, and to determine the risk factors that influence the prognosis. The number of patients that achieved various outcomes was counted and analyzed statistically. A survival curve was drawn using the Kaplan-Meier method, and the difference was compared using the log-rank test. COX regression multivariate analysis was applied to analyze risk factors for the prognosis of peptic ulcer patients. CONCLUSION: After the occurrence of peptic ulcer bleeding, continuing antithrombotics increases the risk of recurrent bleeding events, while discontinuing antithrombotics would increase the risk of death and developing cardiovascular disease. This suggests that clinicians should comprehensively consider the use of antithrombotics after peptic ulcer bleeding.
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Wang et al. (2017) conducted a cohort in Peptic ulcer bleeding. Continuing antithrombotics vs. Discontinuing antithrombotics was evaluated on Recurrent bleeding events, death, and cardiovascular disease (p=0.028). Continuing antithrombotics after peptic ulcer bleeding increased the risk of recurrent bleeding, while discontinuation increased the risk of death and cardiovascular disease (P=0.028).
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