Why the study?
In patients on chronic anticoagulation who suffer peptic ulcer bleeding, the risk-benefit equation of resuming anticoagulation remains undefined.
Does resuming anticoagulation reduce thrombosis and death in adult patients after an index episode of peptic ulcer bleeding while on chronic anticoagulation?
Cohort (n=70)
No
Does resuming anticoagulation reduce thrombosis and death in adult patients after an index episode of peptic ulcer bleeding while on chronic anticoagulation?
Resuming anticoagulation after an episode of peptic ulcer bleeding significantly reduces the risk of thrombosis and death without a significant increase in recurrent bleeding.
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Calo et al. (2020) conducted a cohort in Peptic ulcer bleeding while on chronic anticoagulation (n=70). Resumption of anticoagulation vs. No resumption of anticoagulation was evaluated on Composite of thrombosis and mortality (HR 0.14, 95% CI 0.05-0.43, p=<0.001).
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