Key result
Older age was associated with 0.2-fold higher pulse wave velocity and 25.6% higher oxLDL compared to younger adults (p<0.001), whereas habitual exercise showed no significant association.
Why the study?
The roles of FGF21 and adiponectin in mediating oxidative stress and arterial stiffness with ageing and habitual exercise were unknown.
Is the FGF21-adiponectin axis associated with oxidative stress and arterial stiffness in the context of ageing and habitual exercise in healthy adults?
Population
Eighty age- and sex-matched healthy individuals
Comparison
Younger sedentary vs younger active vs older sedentary vs older active
Design
Cross-sectional study
Authors
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Ageing-related vascular changes should not yet alter exercise advice in healthy adults; leaves open FGF21-adiponectin mediation and requires prospective trials.
Cross-Sectional (n=80)
Is the FGF21-adiponectin axis associated with oxidative stress and arterial stiffness in the context of ageing and habitual exercise in healthy adults?
Effect estimate: 0.2-fold higher PWV and 25.6% higher oxLDL
p-value: p=<0.001
Ageing, but not habitual exercise, is associated with increased arterial stiffness and oxidative stress, which do not appear to be mediated by FGF21 or adiponectin in healthy adults.
Lee et al. (2020) conducted a cross-sectional in Healthy (n=80). Ageing and habitual exercise vs. Younger age and sedentary lifestyle was evaluated on Pulse wave velocity (PWV) and oxLDL concentration (0.2-fold higher PWV and 25.6% higher oxLDL, p=<0.001). Older age was associated with 0.2-fold higher pulse wave velocity and 25.6% higher oxLDL compared to younger adults (p<0.001), whereas habitual exercise showed no significant association.
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