Key result
Transaortic constriction in mice increases blood EPCs to ~210% and stimulates extra-cardiac neoangiogenesis.
Population
C57/Bl6 mice, endothelial nitric oxide synthase double knockout mice, and mice transplanted with green…
Comparison
Transaortic constriction to induce pressure… vs Sham-operated mice
Design
Preclinical
Follow-up
35 days
Authors
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No immediate clinical implications for pressure-overload states; leaves open whether EPC mobilization extends to human cardiac remodeling.
p-value: p=<0.01
Pressure-induced myocardial hypertrophy leads to the systemic upregulation of endothelial progenitor cells and increased angiogenesis, a process dependent on endothelial nitric oxide synthase.
Müller et al. (2007) studied Pressure-induced cardiac overload. Transaortic constriction (TAC) vs. Sham-operated mice was evaluated on Endothelial progenitor cells (EPC) in blood (p=<0.01). Transaortic constriction-induced pressure overload in mice significantly increased systemic endothelial progenitor cells in the blood to 210% (P<0.01) and extra-cardiac neoangiogenesis.
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