Why the study?
Does ramipril prevent maladaptive cardiac remodeling and promote neoangiogenesis in a mouse model of pressure overload?
Population
C57/Bl6 mice with cardiac hypertrophy induced by transaortic constriction (TAC)
Comparison
Ramipril 5 mg/kg p.o. for 5 weeks vs Vehicle treatment
Design
Preclinical
Follow-up
5 weeks
Authors
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Hypothesis-generating in TAC mice; leaves open translation of anti-remodeling effects to human pressure-overload states.
Does ramipril prevent maladaptive cardiac remodeling and promote neoangiogenesis in a mouse model of pressure overload?
ACE inhibition with ramipril prevents maladaptive cardiac hypertrophy and promotes neoangiogenesis via upregulation of endothelial progenitor cells in a mouse model of pressure overload.
Müller et al. (2009) studied this question.
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