Key result
IV sialidase selectively prevents lymphocyte attachment in peripheral lymph node HEVs but not Peyer's patches.
Population
In vivo animal model for studying high endothelial venules in peripheral lymph nodes and Peyer's patches
Design
Preclinical
Authors
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Sialidase selectively disrupts lymphocyte homing to peripheral lymph nodes in mice; leaves open whether sialic acid targeting can modulate immune responses in disease.
Intravenously injected sialidase selectively inactivates attachment sites for lymphocytes on high endothelial venules in peripheral lymph nodes, confirming that sialic acid is required for the adhesive function of PN HEV-ligands.
Rosen et al. (1989) studied this question. Intravenously injected sialidase was evaluated on Lymphocyte attachment to high endothelial venules (HEV). Intravenously injected sialidase selectively prevents lymphocyte attachment and accumulation in peripheral lymph node high endothelial venules, but not in Peyer's patches.
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