Key result
Universal polysome profiling protocol enables protein translation studies across human, mouse, and parasite models.
Population
Parasite Leishmania major, cultured human cells, and mouse testis
Design
Preclinical
Authors
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Offers standardized polysome profiling across parasites and mammals; extends methodology but leaves clinical translation open.
This paper presents a universal polysome profiling protocol adaptable to diverse biological models including parasites, cultured human cells, and animal tissues.
Karamysheva et al. (2018) studied this question. Polysome profiling protocol was evaluated. A universal polysome profiling protocol was successfully adapted for use in the parasite Leishmania major, cultured human cells, and mouse testis to study protein translation regulation.
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