Key result
High-density GH binding localizes to specific brain and spinal regions via units distinct from prolactin.
Population
Male Sprague-Dawley rats
Design
Preclinical
Authors
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No immediate clinical implications; hypothesis-generating for central GH signaling in rodents and warrants human translation studies.
This preclinical study characterizes the specific binding sites for growth hormone in various regions of the rat brain, demonstrating distinct binding units from prolactin.
Zhai et al. (1994) studied this question. 125I-labelled rat growth hormone was evaluated on Growth hormone binding density, affinity, and capacity in different brain areas. High density of growth hormone binding was found in the choroid plexus, hypothalamus, hippocampus, pituitary, and spinal cord, with binding units distinct from those for prolactin.
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