August 1, 2002Journal of Bone and Mineral Research

Localization and Regulation of the Growth Hormone Receptor and Growth Hormone-Binding Protein in the Rat Growth Plate

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Population

Rat growth plate models including normal rats, GH-deficient dwarf rats, and hypophysectomized rats

Comparison

Hormonal treatments including thyroid hormones… vs Untreated hypophysectomized rats, untreated…

Design

Preclinical

Authors

EGEvelien GeversQueen Mary University of London BEBram C. J. van der EerdenErasmus MC MKMarcel KarperienBioengineering Center

Discussion

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Implication

Preclinical rat data warrant no change in GH therapy; leaves open translational role of GHR/GHBP in human growth plate maturation.

Structured PICO

Population

Rat growth plate models including normal rats (e.g., 12-week-old), GH-deficient dwarf rats, and hypophysectomized (Hx) rats

Intervention

Hormonal treatments including thyroid hormones (T3 + T4) via subcutaneous osmotic minipumps, combined growth hormone (GH) and thyroid hormones, or dexamethasone

Comparator

Untreated hypophysectomized rats, untreated normal rats

Outcome

Localization and regulation of Growth Hormone Receptor (GHR) and Growth Hormone-Binding Protein (GHBP) in the growth platesurrogate

GHR and GHBP in the rat growth plate are under hormonal control and localize to early maturing chondrocytes, suggesting GH plays a role in their differentiation.

Cite This Study

Gevers et al. (2002) studied this question.

synapsesocial.com/papers/6a952bc6dd1b902261fa5a3e https://doi.org/10.1359/jbmr.2002.17.8.1408

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Localization and Regulation of the Growth Hormone Receptor and Growth Hormone-Binding Protein in the Rat Growth Plate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Localization and Regulation of the Growth Hormone Receptor and Growth Hormone-Binding Protein in the Rat Growth Plate

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider