Key result
Exposure to growth hormone and insulin-like growth factor-I decreased GHR and IGF-IR mRNA in proliferative cells and increased the number of apoptotic cells across all ages and zones.
The susceptibility of proliferative cells to GHR and IGF-IR down-regulation during peak apoptosis supports a role for the GH-IGF axis in both proliferation and apoptosis during growth plate development.
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Hypothesis-generating for GH-IGF axis in growth plate apoptosis; should not influence pediatric GH therapy pending human data.
Cruickshank et al. (2005) studied Growth plate development. Growth hormone (GH) and insulin-like growth factor-I (IGF-I) was evaluated on Expression of GHR and IGF-IR mRNA and apoptosis. Exposure to growth hormone and insulin-like growth factor-I decreased GHR and IGF-IR mRNA in proliferative cells and increased the number of apoptotic cells across all ages and zones.
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