Key result
Type 1 diabetes mellitus was associated with a significantly higher corrected index of cardiac electrophysiological balance (iCEBc) compared to healthy controls (5.1 vs 4.7, p<0.001).
Why the study?
Type 1 diabetes mellitus carries a risk of cardiac arrhythmias and sudden death, and the relationship between T1DM and the novel ECG parameter index of cardiac electrophysiological balance (iCEB) had not been evaluated.
Does Type 1 Diabetes Mellitus alter the index of cardiac electrophysiological balance (iCEB) compared to healthy individuals?
Case-Control (n=100)
No
Does Type 1 Diabetes Mellitus alter the index of cardiac electrophysiological balance (iCEB) compared to healthy individuals?
Absolute Event Rate: 5.1% vs 4.7%
p-value: p=<0.001
Patients with Type 1 Diabetes Mellitus have a significantly increased corrected index of cardiac electrophysiological balance (iCEBc), suggesting it may be a useful marker for evaluating ventricular arrhythmia risk in this population.
Background: Type 1 diabetes mellitus (T1DM) has been suggested to carry the risk of developing cardiac arrhythmias. The risk of cardiovascular events and sudden death is higher in patients with T1DM. The index of cardiac electrophysiological balance (iCEB), which shows the balance between ventricular depolarization and repolarization, is a new electrocardiographic (ECG) parameter when compared to other ECG parameters. iCEB provides more information on ventricular arrhythmo-genesis than the other traditional ECG parameters such as QT and corrected QT (QTc) intervals. The aim of this study is to evaluate the relationship between T1DM and iCEB.Materials and Methods: This study was conducted retrospectively. The patient group consisted of 50 patients (58% male, mean age 32.9 ± 8.7 years) diagnosed with T1DM, while the control group consisted of 50 healthy individuals (58% male, mean age 33.9 ± 6.8 years). The clinical, demo-graphic and ECG records of the patients were obtained from our hospital's medical documentation system. iCEB and corrected iCEB (iCEBc) values of all participants were calculated by dividing the relevant QT and QTc intervals by the QRS duration.Results: Mean PR, QRS, and QT intervals were similar between groups, while mean heart rate and QTc interval were found to be higher in the T1DM group than in healthy subjects [(83.1 ± 9.8 vs 78.9 ± 13.3 bpm, respectively, p = 0.019) and (425 ± 20.4 vs 397.6 ± 10.6 ms, respectively, p < 0.001)]. The iCEBc of the patient group with T1DM was higher than the control group (5.1 ± 0.5 vs 4.7 ± 0.4 ms, p <0.001, respectively). However, there was no significant difference in iCEB be-tween the patient and control groups (4.3 ± 0.4 and 4.3 ± 0.4 ms, respectively, p = 0.402).Conclusions: In our study, iCEBc was found to be significantly increased in T1DM patients com-pared to healthy subjects. Consequently; it is important to evaluate the risk of ventricular ar-rhythmia with iCEBc in T1DM patients.
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Zorlu et al. (2021) conducted a case-control in Type 1 Diabetes Mellitus (n=100). Type 1 Diabetes Mellitus vs. Healthy individuals was evaluated on Corrected index of cardiac electrophysiological balance (iCEBc) (p=<0.001). Type 1 diabetes mellitus was associated with a significantly higher corrected index of cardiac electrophysiological balance (iCEBc) compared to healthy controls (5.1 vs 4.7, p<0.001).
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