What is the clinical evidence from this study?

Study design: Cohort. Population: life-threatening ventricular tachycardia/fibrillation and paroxysmal atrial tachycardia/fibrillation (n=537). Intervention: Termination of AT/AF vs. Continuation of AT/AF. Primary outcome: median interdetection interval between consecutive VT/VF detections (p=< 0.001).

What does this research mean for the field?

In ICD recipients, termination of atrial tachyarrhythmias significantly delays the recurrence of subsequent ventricular tachyarrhythmias from 11 minutes to 71 hours. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To analyze the incidence and temporal relationship of dual tachycardia—ventricular tachycardia or ventricular fibrillation preceded by paroxysmal atrial tachycardia or atrial fibrillation—in dual-chamber implantable cardioverter defibrillator recipients.

September 10, 2026Journal of the American College of CardiologyOpen Access

Do atrial tachyarrhythmias beget ventricular tachyarrhythmias in defibrillator recipients?

Q: What are the key findings of this study?

In ICD recipients, termination of atrial tachyarrhythmias significantly prolonged the median time to the next ventricular tachyarrhythmia detection from 11 minutes to 71 hours (p<0.001).

Q: What does this research mean for the field?

In ICD recipients, termination of atrial tachyarrhythmias significantly delays the recurrence of subsequent ventricular tachyarrhythmias from 11 minutes to 71 hours. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Q: What question did this study set out to answer?

To analyze the incidence and temporal relationship of dual tachycardia—ventricular tachycardia or ventricular fibrillation preceded by paroxysmal atrial tachycardia or atrial fibrillation—in dual-chamber implantable cardioverter defibrillator recipients.

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Key result

In ICD recipients, termination of atrial tachyarrhythmias significantly prolonged the median time to the next ventricular tachyarrhythmia detection from 11 minutes to 71 hours (p<0.001).

Why the study?

Paroxysmal AT or AF is common in patients receiving ICDs for life-threatening VT or VF, but the relationship between AT/AF and VT/VF is unclear.

Key Points

To analyze the incidence and temporal relationship of dual tachycardia—ventricular tachycardia or ventricular fibrillation preceded by paroxysmal atrial tachycardia or atrial fibrillation—in dual-chamber implantable cardioverter defibrillator recipients.
Followed 537 patients receiving the Jewel AF dual-chamber ICD (Model 7250) for 11.4 ± 8.2 months.
Enrolled 398 patients with a history of at least two atrial tachycardia or fibrillation episodes during the preceding year and 139 patients enrolled for ventricular tachyarrhythmias alone.
Dual tachycardias occurred in 20.3% of patients with ventricular tachyarrhythmias, comprising 8.9% of all detected ventricular tachycardia/fibrillation episodes (233 total episodes across 45 patients).
The median duration of atrial tachycardia or fibrillation preceding the initial ventricular event was 1.09 hours (interquartile range, 0.24 to 33.4 hours).
Persistent atrial arrhythmias between consecutive ventricular detections yielded a median interdetection interval of 11 minutes, whereas termination of the atrial arrhythmia prolonged the median interval to 71 hours (p < 0.001).

Study Design

Type

Cohort (n=537)

PICO

Population

537 patients undergoing implantation of a dual-chamber ICD, including those with a history of AT/AF or VT/VF alone, followed for a mean of 11.4 months.

Exposure / Comparator

Termination of AT/AF vs Continuation of AT/AF

Primary Outcome

median interdetection interval between consecutive VT/VF detections, p=< 0.001

Main Result

p-value: p=< 0.001

Discussion

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Implication

Cohort study reveals frequent dual tachycardias in defibrillator recipients, indicating that terminating atrial arrhythmias significantly delays recurrent ventricular tachyarrhythmias.

Cite This Study

Steín et al. (2002) conducted a cohort in life-threatening ventricular tachycardia/fibrillation and paroxysmal atrial tachycardia/fibrillation (n=537). Termination of AT/AF vs. Continuation of AT/AF was evaluated on median interdetection interval between consecutive VT/VF detections (p=< 0.001). In ICD recipients, termination of atrial tachyarrhythmias significantly prolonged the median time to the next ventricular tachyarrhythmia detection from 11 minutes to 71 hours (p<0.001).

synapsesocial.com/papers/6aa2ca5ab8bd820bf0fe5304 https://doi.org/10.1016/s0735-1097(02)01957-5

Topics

Ventricular arrhythmias Atrial fibrillation Cardiac device therapy Persistent AF management AF ablation outcomes

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Implication

Cohort study reveals frequent dual tachycardias in defibrillator recipients, indicating that terminating atrial arrhythmias significantly delays recurrent ventricular tachyarrhythmias.

Do atrial tachyarrhythmias beget ventricular tachyarrhythmias in defibrillator recipients?

Key Points

Study Design

PICO

Main Result

Discussion

Implication

Cite This Study

Topics

Do atrial tachyarrhythmias beget ventricular tachyarrhythmias in defibrillator recipients?

Key Points

Study Design

PICO

Main Result

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider