Key result
Acute administration of oestradiol caused vasodilation in males but did not alter vasoconstrictor responses to angiotensin I (-42% vs -48% for placebo) or angiotensin II (-39% vs -42%).
Why the study?
Does acute administration of oestradiol or medroxy-progesterone affect resting vascular tone, angiotensin converting enzyme activity, and angiotensin II-induced vasoconstriction in males?
Population
8 male volunteers
Comparison
Oestradiol and medroxy-progesterone vs Placebo
Design
RCT, randomised in a crossover design
Authors
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Acute oestradiol vasodilation in healthy males occurs independently of ACE activity or angiotensin II responses; extends mechanistic evidence for direct estrogen vascular effects.
RCT (n=8)
crossover
Does acute administration of oestradiol or medroxy-progesterone affect resting vascular tone, angiotensin converting enzyme activity, and angiotensin II-induced vasoconstriction in males?
Acute administration of oestradiol causes vasodilation in men, but this effect is not mediated by alterations in vascular ACE activity or sensitivity to angiotensin II.
Lee et al. (2000) reported an RCT. Oestradiol and medroxy-progesterone vs. Placebo was evaluated on Vasoconstriction to angiotensin I and angiotensin II (percentage reduction in forearm flow). Acute administration of oestradiol caused vasodilation in males but did not alter vasoconstrictor responses to angiotensin I (-42% vs -48% for placebo) or angiotensin II (-39% vs -42%).
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