Key result
Imaging techniques, including ultrasound, CT, MRI, and advanced modalities, offer non-invasive alternatives to biopsy for the diagnosis, staging, and follow-up of metabolic liver diseases.
Why the study?
Metabolic liver diseases are a growing global health concern, making non-invasive imaging alternatives to biopsy important for diagnosis, staging, and follow-up.
This review provides a comprehensive overview of non-invasive imaging modalities for the diagnosis and management of metabolic liver diseases.
Supports reduced biopsy reliance via imaging in metabolic liver disease; leaves open need for prospective validation before practice change.
Metabolic liver diseases represent a growing global health concern with significant diagnostic and prognostic implications. Imaging offers non-invasive alternatives to biopsy for diagnosis, staging, and follow-up. This review summarizes current imaging techniques used in metabolic liver disease, including ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), and advanced modalities such as MRI elastography and PET/MRI. Particular focus is given to quantitative biomarkers such as elastography, proton density fat fraction (PDFF) and R2* mapping, their clinical utility, and future directions in artificial intelligence and radiomics. A practical framework for imaging-based assessment is proposed to aid clinicians and radiologists in optimizing patient management.
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Asmundo et al. (2026) conducted a review in Metabolic liver disease. Imaging techniques (US, CT, MRI, elastography, PET/MRI) vs. Biopsy was evaluated. Imaging techniques, including ultrasound, CT, MRI, and advanced modalities, offer non-invasive alternatives to biopsy for the diagnosis, staging, and follow-up of metabolic liver diseases.
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