Key result
LD-1/LD-4 ratio outperforms LD-1/LD-2 for diagnosing MI by yielding higher likelihood ratios.
Why the study?
Does the LD-1/LD-4 ratio provide better diagnostic efficiency for myocardial infarction compared to other LD ratios?
Case-Control (n=285)
Does the LD-1/LD-4 ratio provide better diagnostic efficiency for myocardial infarction compared to other LD ratios?
The LD-1/LD-4 ratio demonstrates superior diagnostic efficiency for myocardial infarction compared to the traditional LD-1/LD-2 ratio.
No takes yet. Share an insight, caveat, or question.
LD-1/LD-4 may aid MI diagnosis when troponin unavailable; hypothesis-generating for prospective validation against current biomarkers.
Loughlin et al. (1988) conducted a case-control in Myocardial infarction (n=285). Lactate dehydrogenase isoenzyme-1 ratios (LD-1/LD-2, LD-1/LD-3, LD-1/LD-4, LD-1/LD-5) vs. Patients with congestive heart failure or nonmyocardial infarct was evaluated on Diagnostic efficacy for myocardial infarction (likelihood ratios). The LD-1/LD-4 ratio yielded the highest likelihood ratio for diagnosing myocardial infarction, increasing by 1.7 to 3.4 times over control values, suggesting it is superior to LD-1/LD-2.
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