Key result
The interstitial compartment holds only 6% of total cardiac adenosine in rat and dog hearts.
The study demonstrates that the majority of the cardiac adenosine pool is intracellular and bound to S-adenosylhomocysteine hydrolase, though its functional role remains uncertain.
Most cardiac adenosine resides intracellularly in animal models; leaves open its functional role and human interstitial relevance.
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Olsson et al. (1982) studied this question. In rat and dog hearts, the cardiac adenosine pool contains an intracellular compartment, with the interstitial compartment accounting for only 6% of the total cardiac pool.
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