Key result
Intracoronary adenosine significantly slowed the rate of ATP depletion, glycogen utilisation, and lactate accumulation during the first 20 minutes of total ischaemia in excised canine myocardium.
Why the study?
Does adenosine slow ischaemic metabolism in totally ischaemic canine myocardium?
Does adenosine slow ischaemic metabolism in totally ischaemic canine myocardium?
Adenosine slows ischemic metabolism in a canine in vitro model, supporting its role in mediating ischemic preconditioning.
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Supports adenosine-mediated preconditioning in canine ischemia; leaves open translation to human cardioprotection.
Heide et al. (1993) studied Ischaemic myocardium (n=13). Adenosine vs. Control bed from the same heart was evaluated on Tissue levels of ATP and glycolytic intermediates (rate of ATP depletion, glycogen utilisation, and lactate accumulation). Intracoronary adenosine significantly slowed the rate of ATP depletion, glycogen utilisation, and lactate accumulation during the first 20 minutes of total ischaemia in excised canine myocardium.
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