May 1, 1996Cardiovascular Research

Effect of adenosine therapy at reperfusion on myocardial infarct size in dogs

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Why the study?

Does intravenous adenosine therapy at reperfusion reduce myocardial infarct size in a canine model of regional myocardial ischemia?

Structured PICO

Does intravenous adenosine therapy at reperfusion reduce myocardial infarct size in a canine model of regional myocardial ischemia?

Population

Dogs (n=37) of either sex subjected to 90 min of coronary occlusion followed by 3 h of reperfusion.

Intervention

Adenosine (150 micrograms/kg/min) intravenously for 155 min starting 5 min prior to reperfusion, administered alone or with lidocaine (2 mg/kg).

Comparator

Saline infusion.

Outcome

Infarct size measured and expressed as a percentage of the ischemic area at risk (AAR) after 3 h of reflow.surrogate

Intravenous adenosine therapy at reperfusion, with or without lidocaine, failed to limit myocardial infarct size in a canine model of ischemia-reperfusion.

Discussion

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Implication

No support for adenosine at reperfusion in this canine model; leaves open translation to other species or clinical settings.

Cite This Study

VANDERHEIDE et al. (1996) studied this question.

synapsesocial.com/papers/6a1feaec2065d284090da3f4 https://doi.org/10.1016/0008-6363(95)00235-9

Topics

Women and heart disease

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Effect of adenosine therapy at reperfusion on myocardial infarct size in dogs

Structured PICO

Discussion

Implication

Cite This Study

Topics

Effect of adenosine therapy at reperfusion on myocardial infarct size in dogs

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider