Key result
Local adenosine during reperfusion increases regional blood flow ~368%, improving O2 supply balance.
Why the study?
Does local adenosine infusion improve regional blood flow and O2 supply to consumption balance in reperfused canine myocardium?
Does local adenosine infusion improve regional blood flow and O2 supply to consumption balance in reperfused canine myocardium?
Absolute Event Rate: 267% vs 57%
Local adenosine infusion during reperfusion mobilizes flow reserve to improve the oxygen supply-to-consumption balance in a canine model of myocardial ischemia.
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May improve reperfusion oxygen balance in canines; leaves open translation to human myocardial ischemia.
Gerlock et al. (1991) studied Reperfused myocardium (n=25). Local adenosine infusion vs. Reperfusion without adenosine was evaluated on Regional blood flow in the affected area (ml.min-1.100 g-1). Local adenosine infusion during reperfusion increased regional blood flow to 267 ml/min/100g compared to 57 ml/min/100g with reperfusion alone, improving the O2 supply to consumption balance.
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