Adenosine infusion during early reperfusion failed to limit myocardial infarct size in a collateral deficient species

Q: What is the clinical evidence from this study?

Population: Myocardial infarction (n=60). Intervention: Intravenous adenosine (with or without lignocaine) vs. Untreated. Primary outcome: Myocardial infarct size (% of area at risk).

Mahiko Goto; Tetsuji Miura; E. K Iliodoromitis; E. L O'Leary; Row Ishimoto; Derek M. Yellon; Osamu Iimura

doi:10.1093/cvr/25.11.943

November 1, 1991Cardiovascular Research

Adenosine infusion during early reperfusion failed to limit myocardial infarct size in a collateral deficient species

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Why the study?

Does intravenous adenosine during early reperfusion reduce myocardial infarct size in a rabbit model of ischemia-reperfusion?

Structured PICO

Does intravenous adenosine during early reperfusion reduce myocardial infarct size in a rabbit model of ischemia-reperfusion?

P

Population

60 anaesthetised open chest rabbits undergoing 30 min occlusion of the circumflex coronary artery followed by reperfusion.

I

Intervention

Intravenous adenosine (high dose 0.37 mg.kg-1.min-1 or low dose 0.15 mg.kg-1.min-1) with or without lignocaine (5 mg intravenously), infused for 60 min starting 5 min before the onset of reperfusion

C

Comparator

Untreated control groups undergoing the same occlusion and reperfusion protocol

O

Outcome

Myocardial infarct size as a percentage of area at risksurrogate

Main Result

Absolute Event Rate: 33.2% vs 39.7%

Intravenous adenosine during early reperfusion, with or without lignocaine, fails to limit myocardial infarct size in a rabbit model lacking significant coronary collaterals.

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Implication

Adenosine fails to limit infarct size in this rabbit model; leaves open its efficacy in human reperfusion or collateralized species.

Abstract

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Cite This Study

Goto et al. (1991) studied Myocardial infarction (n=60). Intravenous adenosine (with or without lignocaine) vs. Untreated was evaluated on Myocardial infarct size (% of area at risk).

synapsesocial.com/papers/6a21bdb47cd64f3298c00498 https://doi.org/10.1093/cvr/25.11.943

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Adenosine infusion during early reperfusion failed to limit myocardial infarct size in a collateral deficient species

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Adenosine infusion during early reperfusion failed to limit myocardial infarct size in a collateral deficient species

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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