Key result
Direct cross transfusions between patients with malignant hypertension and normotensive subjects produced no changes in blood pressure, indicating no increase in circulating pressor substances.
Why the study?
Is arterial hypertension caused by circulating pressor substances?
Population
Patients with malignant hypertension and subjects with normal cardiovascular systems undergoing 4…
Comparison
Direct cross transfusion of 500-2000 cc of… vs Baseline blood pressure; normal dog blood.
Design
Other
Follow-up
Immediate
Authors
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Suggests malignant hypertension is not maintained by circulating pressors; leaves open intrinsic vascular mechanisms for further study.
Is arterial hypertension caused by circulating pressor substances?
This early experimental study provides physiological evidence against the hypothesis that arterial hypertension is maintained by circulating pressor substances.
Prinzmetal et al. (1936) studied Arterial Hypertension (n=8). Direct cross transfusion vs. Normal blood was evaluated on Change in blood pressure. Direct cross transfusions between patients with malignant hypertension and normotensive subjects produced no changes in blood pressure, indicating no increase in circulating pressor substances.
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