Key result
Working hypothesis proposes two distinct mouse lymphocyte lineages based on bone marrow versus thymus origins.
Presents a foundational hypothesis distinguishing between bone marrow-derived and thymus-influenced lymphocytes in mice.
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Distinguishes two lymphocyte populations by origin in mice; leaves open functional validation and translational studies.
A brief review is made of our understanding of the heterogeneity of lymphocytes in the mouse in terms of their anatomic origins. A working hypothesis is presented which is intended to illustrate that there can usefully be recognized at least two kinds of lymphocyte, those which derive directly from the bone marrow and those which, though initially of bonemarrow origin, have come under a differentiational influence within the thymus. The properties of these two kinds of cell are critically considered and various examples are given of the manner in which the hypothesis can be utilized. It must be stressed that the hypothesis is put forward largely for its heuristic value as the evidence for its construction is presently derived almost entirely from small rodents.
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Davies et al. (1971) conducted a review in Lymphocyte heterogeneity. A working hypothesis proposes at least two kinds of lymphocytes in the mouse based on anatomic origins: those derived directly from bone marrow and those influenced by the thymus.
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