Immature B cell homing shapes human lymphoid tissue structure and function

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Theoretical model proposes distinct immature B cell migratory pathways in humans, suggesting differential homing shapes lymphoid tissue function.

Newly formed human transitional B cells diverge into two developmental pathways from bone marrow, which are distinguished by IgM expression levels.
Differential migratory biases guide immature B cell subsets toward distinct lymphoid tissues, establishing functional structural compartmentalization.
Conceptual framework proposes that subset-specific tissue homing governs human lymphoid architecture, highlighting targeted developmental mechanisms.

Spencer et al. (2024) studied this question.

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Theoretical model proposes distinct immature B cell migratory pathways in humans, suggesting differential homing shapes lymphoid tissue function.