Key result
High LINC01279 expression in gastric cancer links to tumor invasion, advanced stage, and worse survival.
Why the study?
To investigate the expression of long non-coding RNA LINC01279 in gastric cancer and its relationship with clinicopathological features and prognosis.
Case-Control (n=180)
p-value: p=<0.05
LINC01279 is highly expressed in gastric cancer and may serve as a prognostic biomarker for tumor invasion and overall survival.
May support LINC01279 as a prognostic biomarker in gastric cancer; leaves open its clinical utility pending prospective validation.
OBJECTIVE: To investigate the expression of long non-coding RNA LINC01279 in gastric cancer and its relationship with the clinicopathological features and prognosis of gastric cancer patients. METHODS: Serum, gastric cancer and adjacent tissue samples from 90-patients with gastric-cancer treated by surgery and serum samples from 90-healthy adults were collected. The expression level of LINC01279 was analyzed by RT-PCR. The clinical baseline data of gastric cancer patients were obtained. Correlation between the expression level of LINC01279 and the clinicopathological characteristics of gastric cancer patients was assessed. RESULTS: LINC01279 was highly expressed in gastric cancer tissues and serum of gastric cancer patients (P < 0.05). The expression level of lncRNA 01279 was closely related to vascular invasion, nerve invasion, T-stage, lymph node metastasis, and advanced clinical-stage of gastric cancer (P < 0.05). The expression level was not correlated with gender, age, tumor size, location, and differentiation. There was a significant negative correlation between the expression of LINC01279 and the overall survival of gastric-cancer patients (P < 0.05). CONCLUSION: LINC01279 is highly expressed in gastric-cancer tissues and serum, which is closely related to tumor-invasion. Serum LINC01279 is a better prognostic indicator of invasive cancer than current tumor markers.
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Song et al. (2021) conducted a case-control in Gastric cancer (n=180). LINC01279 expression vs. Healthy adults and adjacent non-tumor tissue was evaluated on LINC01279 expression levels and correlation with clinicopathological features and overall survival (p=<0.05). High expression of LINC01279 in gastric cancer tissues and serum was significantly associated with tumor invasion, advanced clinical stage, and worse overall survival (P < 0.05).
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