Key result
Acute 99mTc-C2A uptake strongly correlates with later wall motion score index in rat MI models.
Why the study?
Does 99mTc-C2A uptake in the acute phase of myocardial infarction correlate with follow-up cardiac dysfunction in a rat model?
Does 99mTc-C2A uptake in the acute phase of myocardial infarction correlate with follow-up cardiac dysfunction in a rat model?
Effect estimate: R=0.800
p-value: p=0.0006
In a rat ischemia/reperfusion model, acute phase 99mTc-C2A uptake correlates with functional abnormality at 1 and 3 weeks, suggesting its potential as a prognostic imaging agent.
May indicate prognostic value of 99mTc-C2A post-MI; hypothesis-generating in rats, human validation required.
OBJECTIVE: The C2A domain of Synaptotagmin I is a molecular probe for the specific imaging of cell death. Here we test the hypothesis that the uptake of 99mTc-C2A in the acute phase of an infarction is associated with cardiac dysfunction in follow-ups. METHODS: The left coronary artery was occluded in Sprague-Dawley rats for 0, 10, 20, and 30 min. 99mTc-C2A was injected intravenously at 2 h of reperfusion. Anterior planar images were acquired with one million counts on a gamma camera 3 h after injection. 99mTc-C2A uptake was calculated as the total counts in the left ventricle region minus blood pool signal. The in-vivo signal detected was correlated with wall motion score index at 1 and 3 weeks follow-ups measured by echocardiography. RESULTS: 99mTc-C2A uptake was higher with increased ischemic time (2244+/-852, 4054+/-1223, and 6178+/-1451 for 10, 20, and 30 min ischemia, analysis of variance P<0.001). A significant correlation was found between 99mTc-C2A uptake and wall motion score index at 1 week (R=0.800, P=0.0006) and 3 weeks (R=0.810, P=0.0008). CONCLUSION: In this ischemia/reperfusion model, 99mTc-C2A uptake in the acute phase was associated with functional abnormality at 1 and 3 weeks. This demonstrates the potential diagnostic and prognostic value of 99mTc-C2A as a novel imaging agent.
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Zhu et al. (2008) studied Myocardial infarction. 99mTc-C2A was evaluated on Correlation between 99mTc-C2A uptake and wall motion score index at 1 and 3 weeks (R=0.800, p=0.0006). In a rat myocardial infarction model, acute phase 99mTc-C2A uptake significantly correlated with wall motion score index at 1 week (R=0.800, P=0.0006) and 3 weeks (R=0.810, P=0.0008).
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