Differential uptake of myocardial perfusion radiotracers in normal, infarcted, and acutely ischemic peri-infarction myocardium

37 anesthetised pigs with a 1-month old transmural infarction elicited by permanent ligature of the left anterior descending (LAD) coronary artery below the first branch, undergoing one hour of proximal LAD occlusion.

Injection of technetium-99m tetrofosmin (99m Tc) and thallium-201 (201 TI) via left atrium, jugular vein, or left ventricle during cardiocirculatory arrest.

Comparison of radiotracer uptake across normal, acute ischemic, and necrotic (infarct scar) myocardial regions.

Radiotracer counting (uptake of 99m Tc-tetrofosmin and 201Tl) in samples from normal, acute ischemic, and necrotic regions.surrogate