Key result
Intravenous administration of 99mTc-tetracycline resulted in maximum accumulation in experimentally induced lung infarction tissue 5 hours after injection in dogs.
Why the study?
A method for detecting lung infarction using 99mTc-tetracycline accumulation was investigated as a potentially promising clinical tool.
Does 99mtechnetium-tetracycline imaging detect experimentally induced lung infarction in dogs?
Does 99mtechnetium-tetracycline imaging detect experimentally induced lung infarction in dogs?
99mtechnetium-tetracycline shows promising accumulation in experimentally induced lung infarction, suggesting potential utility for clinical detection.
Should not change clinical imaging practice; leaves open translation of 99mTc-tetracycline scintigraphy from this canine model.
In 10 dogs, lung infarction of the right middle and of the left inferior lobe was obtained experimentally. 1 h after operation, 2.0 mCi 99mtechnetium-tetracycline was given intravenously. 5 h after injection, a maximum of accumulation in the infarcted tissue was detected. Conventional perfusion scintigrams were done by injecting 0.2 mCi of 131iodine-albumin particles. Correspondingly, a perfusion reduction in the infarcted area was seen by this technique. This method described seems promising for clinical use for the detection of lung infarction. Clinical studies in this field are in progress.
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Lichey et al. (2009) studied Lung infarction (n=10). 99mTc-tetracycline vs. 131iodine-albumin particles was evaluated on Accumulation in the infarcted tissue. Intravenous administration of 99mTc-tetracycline resulted in maximum accumulation in experimentally induced lung infarction tissue 5 hours after injection in dogs.
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