Key result
99mTc-HL91 fails to detect chronic myocardial ischaemia compared to 201Tl SPECT.
Why the study?
The ability of 99mTc-HL91 to detect regional ischaemia in chronic ischaemic myocardium was unknown.
Does 99mTc-HL91 detect regional ischaemia in chronic ischaemic myocardium compared to 201Tl in a swine model?
Comparison
99mTc-HL91 imaging vs dipyridamole stress-re-injection 201Tl SPECT
Design
Preclinical study
Follow-up
2 hours
Authors
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Questions 99mTc-HL91 for chronic ischaemia imaging; leaves open its evaluation in other models or human studies.
Does 99mTc-HL91 detect regional ischaemia in chronic ischaemic myocardium compared to 201Tl in a swine model?
Absolute Event Rate: 0% vs 80%
99mTc-HL91 is inferior to 201Tl for the scintigraphic detection of chronic myocardial ischemia in a porcine model.
Wu et al. (2005) studied chronic myocardial ischaemia (n=5). 99mTc-HL91 vs. 201Tl SPECT was evaluated on scintigraphic detection of chronic myocardial ischaemia. 99mTc-HL91 failed to detect chronic myocardial ischaemia in any of the 5 mini-pigs (0%), whereas 201Tl SPECT detected significant ischaemia in 80% of the animals.
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