Key result
99mTc-stannous glucoheptonate (TcSnG) successfully identified acute myocardial infarcts in dogs, demonstrating a maximum 20:1 radioactivity ratio of infarcted to normal myocardium at 24 hours.
Why the study?
Does 99mTc-stannous glucoheptonate allow for the detection and localization of acute myocardial infarcts in a dog model?
Population
5 mongrel dogs with acute myocardial infarction induced by surgical ligation of the anterior descending…
Comparison
Intravenous administration of 99mTc-stannous… vs Normal myocardium (within-subject comparison)
Design
Preclinical
Follow-up
24 hours
Authors
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TcSnG shows promise for infarct imaging in canines; leaves open translation to human acute MI detection.
Does 99mTc-stannous glucoheptonate allow for the detection and localization of acute myocardial infarcts in a dog model?
Effect estimate: 20:1 ratio
99mTc-stannous glucoheptonate effectively localizes acute myocardial infarction with a high target-to-background ratio in a canine model.
Bennettt et al. (1974) studied Acute myocardial infarct (n=5). 99mTc-stannous glucoheptonate (TcSnG) was evaluated on Radioactivity ratio of infarcted to normal myocardium (20:1 ratio). 99mTc-stannous glucoheptonate (TcSnG) successfully identified acute myocardial infarcts in dogs, demonstrating a maximum 20:1 radioactivity ratio of infarcted to normal myocardium at 24 hours.
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