What question did this study set out to answer?

Investigate the cellular and morphological mechanisms enabling direct visualization of acute myocardial infarcts using technetium-99m stannous pyrophosphate (99mTc-PYP) scintigraphy.

October 1, 1975CirculationOpen Access

Morphologic correlates of technetium-99m stannous pyrophosphate imaging of acute myocardial infarcts in dogs.

Q: What is the clinical evidence from this study?

Study design: Other. Population: Acute myocardial infarcts (n=22). Intervention: Technetium-99m stannous pyrophosphate (99mTc-PYP) imaging. Primary outcome: Scintigraphic and morphologic correlates of 99mTc-PYP uptake.

Q: What does this research mean for the field?

Technetium-99m stannous pyrophosphate (99mTc-PYP) uptake in acute myocardial infarcts correlates temporally and topographically with calcium accumulation in the peripheral zones of necrotic myocardium. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

View Full Paper

Ask AI

Bookmark

Key result

Technetium-99m stannous pyrophosphate uptake in acute myocardial infarcts in dogs is temporally and topographically related to calcium accumulation in the peripheral zones of the infarcts.

Population

22 dogs subjected to occlusion of the proximal left anterior descending coronary artery (LAD)

Design

Preclinical

Follow-up

Up to 13 days

Authors

LBL. Maximilian BujaGeneral Cardiology RPRobert W. ParkeySouthwestern Medical Center JDJane H. DeesNational Institutes of Health

Discussion

Member takes

Implication

Links 99mTc-PYP uptake to calcium in canine infarct zones; leaves open translation to human imaging.

Key Points

Investigate the cellular and morphological mechanisms enabling direct visualization of acute myocardial infarcts using technetium-99m stannous pyrophosphate (99mTc-PYP) scintigraphy.
Subjected 22 dogs to proximal left anterior descending coronary artery (LAD) occlusion for intervals of 1, 2, 7, or 13 days, alongside temporary 8-minute occlusion with 24-hour reperfusion.
Performed 99mTc-PYP myocardial scintigraphy and correlated scans with gross pathology, histochemistry, and ultrastructural examination of damaged myocardial tissue.
Gross infarcts occurred in 19 dogs, displaying strongly positive 99mTc-PYP scans at days 1 and 2, which diminished by day 7 and appeared faint by day 13; dogs without gross infarcts (n=3) had negative scans.
Scintigrams commonly formed a 'doughnut' pattern with marked peripheral uptake, histologically matching peripheral zones enriched with calcified myocytes containing mitochondrial apatite-like crystals and reduced central uptake.
Infarcts aged 7 to 13 days demonstrated replacement of necrotic tissue by granulation tissue, accompanied by progressive clearance of calcium deposits and declining radioactive tracer uptake.

Structured PICO

Population

22 dogs subjected to occlusion of the proximal left anterior descending coronary artery (LAD)

Intervention

Technetium-99m stannous pyrophosphate (99mTc-PYP) myocardial scintigraphy and morphologic/histologic examination

Outcome

Temporal and topographical relationship between 99mTc-PYP uptake and morphologic/histologic features of myocardial infarctionsurrogate

99mTc-PYP uptake in acute myocardial infarction correlates temporally and topographically with calcium accumulation in the peripheral zones of necrotic myocardium.

Cite This Study

Buja et al. (1975) studied Acute myocardial infarcts (n=22). Technetium-99m stannous pyrophosphate (99mTc-PYP) imaging was evaluated on Scintigraphic and morphologic correlates of 99mTc-PYP uptake. Technetium-99m stannous pyrophosphate uptake in acute myocardial infarcts in dogs is temporally and topographically related to calcium accumulation in the peripheral zones of the infarcts.

synapsesocial.com/papers/6a0de8e76e03bc61cb09fa5b https://doi.org/10.1161/01.cir.52.4.596

View Full Paper

Ask AI

Bookmark

Morphologic correlates of technetium-99m stannous pyrophosphate imaging of acute myocardial infarcts in dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Morphologic correlates of technetium-99m stannous pyrophosphate imaging of acute myocardial infarcts in dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider