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May 1, 1976CirculationOpen Access

Technetium 99m stannous pyrophosphate myocardial imaging in patients with and without left ventricular aneurysm.

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Key result

Technetium 99m pyrophosphate imaging showed localized uptake in 9 of 10 patients with left ventricular aneurysm without acute MI, indicating caution when diagnosing acute MI in these patients.

Why the study?

Does the presence of a left ventricular aneurysm cause false-positive technetium 99m pyrophosphate myocardial scintigrams for acute myocardial infarction?

Population

50 patients, comprising 28 with acute myocardial infarction and 22 with significant coronary artery disease…

Design

Cross-sectional

Authors

MAMasood AhmadThe University of Agriculture, PeshawarJDJ P DubielNew York Academy of MedicineTVThomas A. VerdonWashington Center

Discussion

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Implication

Caution needed interpreting 99mTc-PYP scans with LV aneurysm; challenges consensus but leaves open prospective validation.

Study Design

Type

Observational (n=50)

Structured PICO

Does the presence of a left ventricular aneurysm cause false-positive technetium 99m pyrophosphate myocardial scintigrams for acute myocardial infarction?

P
Population
50 patients, comprising 28 with acute myocardial infarction (15 transmural, 13 subendocardial) and 22 with significant coronary artery disease documented by angiography but without acute myocardial infarction (10 with left ventricular aneurysm, 5 with left ventricular akinesis, 7 with normal left ventricular wall motion).
I
Intervention
Technetium 99m stannous pyrophosphate (99mTc-PYP) myocardial imaging
O
Outcome
Scintigram activity pattern (localized vs diffuse, positive vs negative)surrogate

Positive 99mTc-PYP myocardial scintigrams should be interpreted with caution in diagnosing acute myocardial infarction when a left ventricular aneurysm is present, as aneurysms can cause localized uptake.

Cite This Study

Ahmad et al. (1976) conducted an observational in Acute myocardial infarction and left ventricular aneurysm (n=50). Technetium 99m stannous pyrophosphate (99mTc-PYP) myocardial imaging was evaluated on Myocardial scintigram activity (localized or diffuse). Technetium 99m pyrophosphate imaging showed localized uptake in 9 of 10 patients with left ventricular aneurysm without acute MI, indicating caution when diagnosing acute MI in these patients.

synapsesocial.com/papers/6a0de8e76e03bc61cb09fa56https://doi.org/10.1161/01.cir.53.5.833
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute subendocardial myocardial infarction in patients. Its detection by Technetium 99-m stannous pyrophosphate myocardial scintigrams.1975 · 139 citations
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  3. 3THE ELECTROCARDIOGRAPHIC CLUE TO VENTRICULAR ANEURYSM1951 · 53 citations
  4. 4Measurement of Left Ventricular Volumes in Man by Single-plane Cineangiocardiography1969 · 260 citations
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