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August 1, 1977CirculationOpen Access

Technetium-99m stannous pyrophosphate myocardial scintigraphy. Reliability and limitations in assessment of acute myocardial infarction.

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Why the study?

Does Technetium-99m stannous pyrophosphate myocardial scintigraphy accurately detect acute myocardial infarction in patients with chest pain?

Population

203 patients evaluated for chest pain and suspected acute myocardial infarction.

Comparison

Technetium-99m stannous pyrophosphate myocardial… vs Clinical, electrocardiographic, and enzymatic…

Design

Cohort

Authors

MCMichael J. CowleyBoston Medical CenterJMJohn A. MantleNational Institutes of HealthWRWalter J. RogersUniversity of Maryland, Baltimore

Discussion

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Implication

Supports Tc-99m pyrophosphate scintigraphy for acute MI diagnosis when blood pool activity is considered; hypothesis-generating for its role versus modern imaging.

Structured PICO

Does Technetium-99m stannous pyrophosphate myocardial scintigraphy accurately detect acute myocardial infarction in patients with chest pain?

P
Population
203 patients evaluated for chest pain and suspected acute myocardial infarction.
I
Intervention
Technetium-99m stannous pyrophosphate myocardial scintigraphy (routine imaging at 60-90 minutes, immediate blood pool imaging, and delayed studies if needed)
C
Comparator
Clinical, electrocardiographic, and enzymatic (CK-MB) criteria for acute myocardial infarction
O
Outcome
Diagnostic accuracy (positive/negative scintigrams) for acute myocardial infarctionsurrogate

Technetium-99m stannous pyrophosphate myocardial scintigraphy is a reliable diagnostic tool for acute myocardial infarction, provided residual blood pool activity and specific false-positive conditions are accounted for.

Limitations

  • False positive scintigrams can occur following cardioversion and in patients with previous myocardial infarction and resultant ventricular wall motion abnormalities.

Cite This Study

Cowley et al. (1977) studied this question.

synapsesocial.com/papers/6a832e2ec009eb9b7eefe841https://doi.org/10.1161/01.cir.56.2.192
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Technetium stannous pyrophosphate myocardial scintigrams in patients with chest pain of varying etiology.1975 · 209 citations
  2. 2Myocardial Scintigraphy with <sup>99m</sup>Technetium Stannous Pyrophosphate in Patients with Possible Acute Myocardial Infarction1977 · 3 citations
  3. 3Acute subendocardial myocardial infarction in patients. Its detection by Technetium 99-m stannous pyrophosphate myocardial scintigrams.1975 · 139 citations
  4. 4The predictive value of myocardial scintigraphy with <sup>99m</sup>technetium pyrophosphate in diagnosing acute myocardial infarction1979
  5. 5Clinicopathologic findings in 52 patients studied by technetium-99m stannous pyrophosphate myocardial scintigraphy.1979 · 71 citations