July 1, 1977Cardiovascular Research
Infarct sizing with technetium-99m stannous pyrophosphate scintigraphy in dogs and man; relationship between scintigraphic and praecordial mapping estimates of infarct size in patients
Why the study?
Does 99mTc-PYP scintigraphy accurately estimate infarct size in dogs and patients with acute anterior or anterolateral myocardial infarction?
Population
10 dogs with proximal left anterior descending coronary artery occlusion and acute anterior myocardial…
Comparison
Technetium-99m stannous pyrophosphate myocardial… vs Histological infarct weight and praecordial ST…
Design
Cohort
Follow-up
acute
Authors
Discussion
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Member takes
Implication
Supports 99mTc-PYP for infarct sizing in anterior MI; hypothesis-generating and requires prospective validation before clinical use.
Structured PICO
Does 99mTc-PYP scintigraphy accurately estimate infarct size in dogs and patients with acute anterior or anterolateral myocardial infarction?
P
Population
10 dogs with proximal left anterior descending coronary artery occlusion and acute anterior myocardial infarcts, and 25 patients with acute anterior or anterolateral myocardial infarcts.
I
Intervention
Technetium-99m stannous pyrophosphate (99mTc-PYP) myocardial scintigraphy
C
Comparator
Histological infarct weight (in dogs) and praecordial ST segment mapping (in patients)
O
Outcome
Correlation between scintigraphic infarct size and histological infarct weight (dogs) or praecordial ST segment mapping and development of left ventricular failure (patients)surrogate
99mTc-PYP scintigraphy can estimate acute anterior and anterolateral infarct size in both experimental animal models and patients, correlating with histological size and ECG mapping.
Limitations
- Overlap in scintigraphic infarct size between patients who did and did not develop left ventricular failure, presumably due to earlier myocardial damage
Cite This Study
Willerson et al. (1977) studied this question.