Key result
Lower hs-CRP and IL-6 are linked to worse MLHFQ emotional scores.
Observational (n=482)
Effect estimate: β = -0.107
p-value: p=0.003
In patients with coronary artery disease and heart failure, lower levels of inflammatory biomarkers (hs-CRP and IL-6) are paradoxically associated with worse health-related quality of life.
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Paradoxical biomarker-QoL link in HF patients should not change practice; leaves open causal direction and clinical relevance.
Kažukauskienė et al. (2018) conducted an observational in Coronary artery disease and heart failure (n=482). Inflammatory biomarkers (hs-CRP and IL-6) was evaluated on Minnesota Living with Heart Failure Questionnaire emotional subscale (β = -0.107, p=0.003). Lower levels of high-sensitivity C-reactive protein and interleukin-6 were associated with worse scores on the Minnesota Living with Heart Failure Questionnaire emotional subscale (p=0.003 and p=0.004).
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