Key result
The A-1332G transition in the AT2 receptor gene was found in 44% of patients with vesico-ureteric reflux and 42% of healthy controls, suggesting no association with VUR development.
Why the study?
Is mutation of the angiotensin II receptors AT1 and AT2 associated with primary vesico-ureteric reflux in humans?
Case-Control (n=42)
Is mutation of the angiotensin II receptors AT1 and AT2 associated with primary vesico-ureteric reflux in humans?
Absolute Event Rate: 44% vs 42%
Mutations in the AT1 and AT2 receptor genes do not appear to be associated with the development of primary vesico-ureteric reflux.
No evidence supports AT receptor genotyping in VUR; leaves open contributions from other genetic or environmental factors.
OBJECTIVE: To investigate if mutation of the angiotensin II (Ang II) receptors AT2 is involved in primary vesico-ureteric reflux (VUR) in humans. PATIENTS AND METHODS: Genetic polymorphisms in the AT1 and AT2 receptors was evaluated in 23 patients having the most common congenital urological abnormality, namely primary congenital VUR. The occurrence of the A1166C transition in the AT1 receptor gene and the A-1332G transition in the AT2 receptor gene were evaluated and compared with the incidence in normal controls with no urological abnormalities. RESULT: The distribution of the AT1 receptor genotypes was no different between patients with VUR and healthy controls. Furthermore, 10 of 23 (44%) patients with VUR and seven of 19 (42%) controls carried the AT2 receptor gene variation. These results contrast with our previous finding of an association between the A-1332G transition in the AT2 receptor gene and primary obstructive megaureter, and pelvi-ureteric junction obstruction. CONCLUSIONS: We propose that while the AT2 receptor is crucial for the normal development of the ureter, it does not contribute to the processes which culminate in VUR, which is primarily an abnormality in the bladder trigone.
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Hohenfellner et al. (1999) conducted a case-control in primary congenital vesico-ureteric reflux (VUR) (n=42). AT1 and AT2 receptor gene polymorphisms (A1166C and A-1332G transitions) vs. Healthy controls with no urological abnormalities was evaluated on Occurrence of the A-1332G transition in the AT2 receptor gene. The A-1332G transition in the AT2 receptor gene was found in 44% of patients with vesico-ureteric reflux and 42% of healthy controls, suggesting no association with VUR development.
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