Key result
The degree of regional heterogeneity in blood flow and glucose uptake within single skeletal muscles was similar in awake and anaesthetized rabbits.
Population
Awake and anaesthetized rabbits
Comparison
Measurement of regional blood flow and glucose… vs Anaesthetized state
Design
Preclinical
Authors
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Muscle perfusion heterogeneity occurs independently of anesthesia; extends anesthetized observations but leaves open human translation.
Regional perfusion and glucose uptake within single skeletal muscles are markedly heterogeneous in awake rabbits, similar to anaesthetized rabbits, driven by non-synchronized fluctuations in blood flow.
Iversen et al. (1990) studied this question. Awake state vs. Anaesthetized state was evaluated on Regional heterogeneity in blood flow and glucose uptake. The degree of regional heterogeneity in blood flow and glucose uptake within single skeletal muscles was similar in awake and anaesthetized rabbits.
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