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January 24, 2023ChemistrySelect

In Vitro Cytocompatibility and Anti‐biofilm Properties of Electrodeposited Ternary‐Ion‐Doped Hydroxyapatite Coatings on Ti for Orthopaedic Applications

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Authors

ABAnqi BianFJFenghuan JiaZWZongze Wu

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Overview

In vitro study demonstrates near-total bacterial inhibition and enhanced osteoblast cytocompatibility on ion-doped titanium, indicating strong potential for anti-infective orthopaedic implants.

Key Points

  • To develop and evaluate the surface properties, antibacterial efficacy, and cytocompatibility of a novel electrodeposited hydroxyapatite coating co-doped with silver, strontium, and manganese on titanium substrates.
  • Electrodeposited ternary-ion-doped nanohydroxyapatite (MnSrAgHA) onto pure titanium surfaces.
  • Characterized coating microstructure, elemental distribution, thickness, roughness, and hydrophilicity using FE-SEM, XPS, EDS, and contact angle measurements.
  • Assessed antibacterial activity against Staphylococcus aureus and evaluated in vitro osteoblast adhesion, proliferation, differentiation, and cytotoxicity.
  • The electrodeposited MnSrAgHA coating formed a dense, ~10 μm thick layer with flower- and needle-like crystalline clusters while maintaining surface hydrophilicity.
  • MnSrAgHA inhibited Staphylococcus aureus growth with an antibacterial rate of nearly 100%.
  • Cell culture assays showed significantly enhanced osteoblast adhesion, proliferation, and differentiation on MnSrAgHA without significant silver-induced cytotoxicity.

Cite This Study

Bian et al. (2023) studied this question.

synapsesocial.com/papers/6aa368fc240321efda554ab5https://doi.org/10.1002/slct.202203683
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Multifunctional Hydroxyapatite–Barium Titanate Coatings with Green-Synthesized Silver Nanoparticles for Orthopedic Implants: Piezodynamic, Biological, and Antibacterial Evaluation2026 · 1 citations
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