The Differential Effects of HDL Subpopulations on Lipoprotein Lipase (LPL)-Mediated VLDL Catabolism

Figure 1. Percentage of hydrolyzed TG during LPL-mediated VLDL lipolysis in the absence and presence of HDLT and HDL subpopulations: HDL-2 and HDL-3. Data are presented as mean ± SD, n = 10, *** p < 0.001. Data were analyzed by Repeated Measures ANOVA with Tukey post hoc.

Figure 2. Percentage of free cholesterol (A) and phospholipids (B) released from VLDL during LPL-mediated lipolysis in the absence or presence of HDLT and HDL subpopulations: HDL-2 and HDL-3. Data are presented as mean ± SD, n = 10, * p < 0.05; *** p < 0.001. Data were analysed by Repeated Measures ANOVA with Tukey post hoc.

Figure 3. Percentage of apo E (A), apo CII (B) and apo CIII (C) released from VLDL during LPL-mediated lipolysis in the absence or presence of HDLT and HDL subpopulations: HDL-2 and HDL 3. Data are presented as mean ± SD, n = 10, * p < 0.05; *** p < 0.001. Data were analyzed by Repeated Measures ANOVA with Tukey post hoc.

Figure 4. Exemplary electrophoresis and electropherogram of VLDL control and VLDL remnants produced during LPL-mediated lipolysis in the absence or presence of HDLT and HDL subpopulations: HDL-2 and HDL-3; ß mobility corresponds to LDL, pre-ß mobility corresponds to VLDL, ɑ mobility corresponds to HDL.

Figure 5. Relative electrophoretic mobility of VLDL remnants produced during LPL-mediated lipolysis in the absence or presence of HDLT and HDL subpopulations: HDL 2 and HDL-3. Data are presented as mean ± SD, n = 10, * p < 0.05; ** p < 0.01; *** p < 0.001. Data were analyzed by Repeated Measures ANOVA with Tukey post hoc.