Key result
Dobutamine stress echocardiography revealed a blunted left ventricular contractile response in 25.4% of patients with liver cirrhosis, suggesting underlying cirrhotic cardiomyopathy.
Why the study?
Does dobutamine stress echocardiography identify blunted cardiac responses indicative of cirrhotic cardiomyopathy in patients with liver cirrhosis?
Population
71 patients with liver cirrhosis and normal left ventricular chamber size and ejection fraction, plus 8…
Comparison
Dobutamine stress echocardiography with peak… vs Healthy controls and cirrhotic patients with a…
Design
Cross-sectional
Authors
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Supports consideration of stress echocardiography in cirrhosis; hypothesis-generating pending prospective validation.
Observational (n=79)
Single-blind
No
Does dobutamine stress echocardiography identify blunted cardiac responses indicative of cirrhotic cardiomyopathy in patients with liver cirrhosis?
Absolute Event Rate: 25.4% vs 0%
Dobutamine stress echocardiography can unmask latent systolic dysfunction indicative of cirrhotic cardiomyopathy in approximately 25% of patients with liver cirrhosis who have normal resting cardiac function.
Kim et al. (2010) conducted an observational in Liver cirrhosis (n=79). Dobutamine stress echocardiography vs. Healthy controls was evaluated on Blunted left ventricular response to dobutamine (decrease <10% in EDV, <20% in ESV, and increase <10% in EF). Dobutamine stress echocardiography revealed a blunted left ventricular contractile response in 25.4% of patients with liver cirrhosis, suggesting underlying cirrhotic cardiomyopathy.