Key result
Lipoprotein lipase activity in multiple rat tissues emerges substantially within 24 hours of birth.
No direct clinical implications for neonates; leaves open human translation of rat perinatal LPL patterns.
The lipoprotein lipase activity of the lung, skeletal muscle, heart muscle and brown adipose tissue of the rat was studied during the period from late foetal to adult life. The enzyme activity in all four tissues emerged substantially during the first 24th after birth. Subsequently, heart and lung enzyme activity remained relatively constant per unit wet weight of tissue. The enzyme activity present in brown adipose tissue and skeletal muscle was elevated per unit weight of tissue during suckling compared with other periods of life. Delivery of near-term foetuses stimulated the emergence of enzyme activity in all four tissues with the same time course as that evoked by normal delivery. The significance of the presence of the enzyme in the tissues and the activity changes which occurred during development are discussed in relation to possible mechanisms of control.
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Cryer et al. (1978) studied this question. Developmental stage (late foetal to adult life) was evaluated on Lipoprotein lipase activity in lung, skeletal muscle, heart muscle and brown adipose tissue. Lipoprotein lipase activity in rat lung, skeletal muscle, heart muscle, and brown adipose tissue emerged substantially during the first 24 hours after birth.
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