Key result
Coxsackievirus B3 replicates robustly in lymphoid cell lines but produces minimal infectious virus in PBMCs.
Population
Human peripheral blood mononuclear cells, granulocytes, bone marrow cells, and lymphoid cell lines
Design
Preclinical
Authors
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Primary leukocytes unlikely to drive substantial coxsackievirus amplification; hypothesis-generating for myocarditis pathogenesis and cell tropism.
While lymphoid cell lines support robust Coxsackievirus B3 replication, primary human leukocytes and bone marrow cells produce minimal infectious virus, suggesting limited role of these primary cells in viral amplification.
Vuorinen et al. (1994) studied Coxsackievirus B3 infection. Coxsackievirus B3 infection was evaluated on Virus replication and protein synthesis in human leukocytes and lymphoid cell lines. Coxsackievirus B3 replicates to high titers in B- and T-cell lymphoid cell lines, but produces only diminutive amounts of infectious virus in isolated peripheral blood mononuclear cells and granulocytes.
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