Key result
The A allele of PEAR1 rs12041331 was significantly associated with an increased risk of ischemic events in patients with coronary artery disease (OR 1.40; 95% CI 1.04-1.88; p=0.03).
Why the study?
The study was conducted to evaluate the association between PEAR1 polymorphisms and ischemic clinical outcomes in patients with coronary artery disease.
Are PEAR1 polymorphisms associated with an increased risk of ischemic clinical outcomes in patients with coronary artery disease?
Meta-Analysis (n=9,914)
Are PEAR1 polymorphisms associated with an increased risk of ischemic clinical outcomes in patients with coronary artery disease?
Odds Ratio: 1.4 (95% CI 1.04–1.88)
p-value: p=0.03
PEAR1 genetic variants rs12041331 and rs2768759 are significantly associated with an increased risk of ischemic events in patients with coronary artery disease.
May support PEAR1 genotyping in CAD risk models; confirms association but requires prospective validation.
Aim: The aim of this study was to assess the association between PEAR1 polymorphisms and ischemic clinical outcomes. Materials & methods: We searched the electronic database for articles on the relationship of PEAR1 SNPs and ischemic events in patients with coronary artery disease (CAD) up to October 2020. Results: A total of 9914 patients with CAD from six studies focusing on 12 SNPs of PEAR1 were included in this study. The A allele of rs12041331 were associated with ischemic events (odds ratio: 1.40; 95% CI: 1.04–1.88; p = 0.03). The AA homozygotes of rs2768759 was related to a higher risk of ischemic events than carriers of the C allele (odds ratio: 2.08; 95% CI: 1.09–3.97; p = 0.03). Conclusion: PEAR1 rs12041331 and rs2768759 are significantly associated with ischemic events in patients with CAD.
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Zhang et al. (2021) conducted a meta-analysis in Coronary artery disease (CAD) (n=9,914). PEAR1 polymorphisms (rs12041331 A allele) vs. Non-carriers was evaluated on Ischemic events (OR 1.40, 95% CI 1.04-1.88, p=0.03). The A allele of PEAR1 rs12041331 was significantly associated with an increased risk of ischemic events in patients with coronary artery disease (OR 1.40; 95% CI 1.04-1.88; p=0.03).
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