Key result
Carriage of the PEAR1 rs56260937 minor allele was independently associated with a higher risk of 1-year revascularization events (OR 2.15) in Chinese patients with acute myocardial infarction after percutaneous coronary intervention.
Why the study?
Does carriage of PEAR1 genetic variants predict adverse ischemic events in Chinese patients with acute myocardial infarction after percutaneous coronary intervention?
Cohort (n=647)
No
Does carriage of PEAR1 genetic variants predict adverse ischemic events in Chinese patients with acute myocardial infarction after percutaneous coronary intervention?
Odds Ratio: 2.15 (95% CI 1.12–4.15)
Absolute Event Rate: 16.7% vs 8.6%
p-value: p=0.022
Carriage of the PEAR1 rs56260937 minor allele independently predicts an increased risk of revascularization at 1 year in Chinese patients with AMI undergoing PCI on standard dual antiplatelet therapy.
AIMS: Platelet endothelial aggregation receptor-1 (PEAR1) is a platelet transmembrane protein that plays an important role on platelet aggregation. The aim of this study was to investigate whether PEAR1 genetic variations are associated with 1-year outcomes in Chinese patients with acute myocardial infarction after percutaneous coronary intervention. METHODS: A total of 647 consecutive Chinese patients with acute myocardial infarction that underwent percutaneous coronary intervention and that were exposed to standard dual antiplatelet therapy with aspirin and clopidogrel were enrolled in this study. Six single nucleotide polymorphisms of PEAR1 were detected using the ligase detection reaction method. The follow-up period was 12 months. RESULTS: Overall, 66 (10.2%) adverse ischemic events occurred. Multivariate Cox regression analysis showed that carriage of the PEAR1 rs56260937 minor allele was an independent predictor of revascularization events (OR=2.15, 95% CI 1.12-4.15, p=0.022) after adjusting for confounding factors. CONCLUSIONS: Genetic testing for PEAR1 variants can be helpful in predicting adverse ischemic events in Chinese patients with acute myocardial infarction after percutaneous coronary intervention.
No takes yet. Share an insight, caveat, or question.
Yao et al. (2017) conducted a cohort in Acute Myocardial Infarction (AMI) after Percutaneous Coronary Intervention (PCI) (n=647). PEAR1 rs56260937 minor allele (TT genotype) vs. PEAR1 rs56260937 major allele carriers (CC or CT genotype) was evaluated on Revascularization events at 1 year (OR 2.15, 95% CI 1.12-4.15, p=0.022). Carriage of the PEAR1 rs56260937 minor allele was independently associated with a higher risk of 1-year revascularization events (OR 2.15) in Chinese patients with acute myocardial infarction after percutaneous coronary intervention.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: